1402736-98-4

Upstream product

• 611-01-8 2,4-dimethyl-benzoic acid 
• 651-83-2 4-trifluoromethyl-2,3,5,6-tetrafluoroaniline 
• 21900-42-5 2,4-dimethylbenzoyl chloride 

Downstream Products

• 1388233-78-0 2,4-dimethyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-6-(trifluoromethyl)benzamide 
• 1465827-41-1 2,4-dimethyl-6-morpholino-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)benzamide 

Relevant academic research and scientific papers

Pd(II)-catalyzed ortho trifluoromethylation of arenes and insights into the coordination mode of acidic amide directing groups

A Pd(II)-catalyzed trifluoromethylation of ortho C-H bonds with an array of N-arylbenzamides derived from benzoic acids is reported. N-Methylformamide has been identified as a crucial promoter of C-CF3 bond formation from the Pd center. X-ray characterization of the C-H insertion intermediate has revealed a rare coordination mode of acidic amides as directing groups and the origin of their capacity in directing C-H activation.