1402743-75-2

Upstream product

• 766556-66-5 tert-butyl [(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-carbamate 
• 16588-74-2 3,5-ditrifluoromethylisocyanate 
• 163061-73-2 (1R,2R)-1-aminoindan-2-ol 
• 1402743-80-9 tert-butyl ((1R,2R)-2-(2-nitro-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate 
• 463-71-8 thiophosgene 
• 1402743-82-1 1-(2-(((1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea 

Relevant academic research and scientific papers

Cooperative assistance in bifunctional organocatalysis: Enantioselective mannich reactions with aliphatic and aromatic imines

Hold them tight: Guided by X-ray structures, bifunctional thiourea catalysts containing an activating intramolecular hydrogen bond were redesigned. The new catalysts were used to effect a highly enantioselective Mannich reaction between malonates and both aliphatic and aromatic imines (see scheme; Boc=tert-butoxycarbonyl).