1402746-78-4

Basic information

• Product Name: 1-(3-chloro-4-fluoro)-3-(4-(2-methyl-6-(4-(2-hydroxyethyl)piperazine-1-yl)pyrimidin-4-yl-amino)phenyl)urea
• CAS NO: 1402746-78-4
• Molecular Weight: 499.975
• Mol File: 1402746-78-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-chloro-4-fluoro)-3-(4-(2-methyl-6-(4-(2-hydroxyethyl)piperazine-1-yl)pyrimidin-4-yl-amino)phenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chloro-4-fluoro)-3-(4-(2-methyl-6-(4-(2-hydroxyethyl)piperazine-1-yl)pyrimidin-4-yl-amino)phenyl)urea(1402746-78-4)
• EPA Substance Registry System: 1-(3-chloro-4-fluoro)-3-(4-(2-methyl-6-(4-(2-hydroxyethyl)piperazine-1-yl)pyrimidin-4-yl-amino)phenyl)urea(1402746-78-4)

Safety Data

• Hazardous Substances Data: 1402746-78-4(Hazardous Substances Data)

Upstream product

• 856976-40-4 6-chloro-2-methyl-N-(4-nitrophenyl)pyrimidin-4-amine 
• 100-01-6 4-nitro-aniline 
• 1780-26-3 2,4-dichloro-2-methylpyrimidine 

Relevant articles and documents

A urea compound, preparation method thereof, wherein the intermediate and its application

Disclosed are urea compounds represented by formula I or pharmaceutically acceptable salts, polymorphic forms, solvates or stereoisomers thereof; as well as preparation methods, intermediates and uses thereof. The urea compounds according to the present invention show various degrees of inhibitory activity against a variety of protein kinases in biological tests, and showed various degrees of activity against tumor cell growth and against angiogenesis in in vitro tests on resistance to the proliferation of human tumor cell line and human umbilical vein endothelial cells (HUVECs) respectively, and also exhibit good antitumor activity in vivo in animals.