1402748-85-9Relevant articles and documents
Decarboxylative allylation of trifluoroethyl sulfones and approach to difluoromethyl compounds
Shibata, Norio,Fukushi, Kazunobu,Furukawa, Tatsuya,Suzuki, Satoru,Tokunaga, Etsuko,Cahard, Dominique
, p. 5366 - 5369,4 (2020/09/02)
Allyl carbonates undergo palladium-catalyzed decarboxylative allylation of trifluoroethyl phenyl sulfones. The success of the allylation, which is not efficient under typical strong base-mediated conditions, is the result of mild conditions thanks to a progressive delivery of ethoxide. Indeed, ethyl allyl carbonates act as a latent source of ethoxide for generation of the trifluoroethyl carbanion that reacts with the π-allylpalladium complex. The utility of the method is illustrated in a new approach to difluoromethyl compounds.