1402749-01-2Relevant academic research and scientific papers
Catalyst-free N-arylation using unactivated fluorobenzenes
Diness, Frederik,Fairlie, David P.
, p. 8012 - 8016 (2012/09/05)
Caught in a 'SNAr'e: A one-step, high-yielding, catalyst-free method is described for N-arylation of azoles and indoles from unactivated monofluorobenzenes. This SNAr reaction tolerates a wide range of substituents and can also generate halogenated N-aryl products. The reaction can also be performed simultaneously with or subsequent to a copper- or palladium-catalyzed cross-coupling reaction in the same pot. Copyright
