1402820-52-3Relevant academic research and scientific papers
Enantioselective total synthesis of amphidinolide F
Mahapatra, Subham,Carter, Rich G.
, p. 7948 - 7951 (2012/09/08)
A common-intermediate approach is utilized in the total synthesis of amphidinolide F (see scheme, left) to access both the C1-C8 and the C18-C25 portions of the macrolide. A silver-catalyzed rearrangement/cyclization was employed to construct the two tetrahydrofuran rings. A Felkin-controlled, dienyl lithium addition to an α-chiral aldehyde incorporated both the C9-C11 diene and the alcohol at C8. An umpolung sulfone alkylation/oxidative desulfurization sequence is employed to couple the two moieties. Copyright
