1402841-92-2Relevant academic research and scientific papers
Synthesis of some 1-(Flavon-7-yl)-4,5-dihydro-1,2,4-triazin-6(1H)-ones and related congeners
Abu-Aisheh, Marwa N.,Mustafa, Mohammad S.,Mubarak, Mohammad S.,El-Abadelah, Mustafa M.,Voelter, Wolfgang
, p. 465 - 473 (2012/10/29)
Herein, a selected set of chiral N1-(4-oxochromen-7-yl)-4,5-dihydro-1,2,4- triazin-6(1H)-ones (7a-k/8a-k) were prepared via direct interaction of L-α-amino esters with N1-(4-oxochromen-7-yl) nitrile imines (generated in situ from their hydrazonoyl chloride precursors 5a,b by the action of triethylamine). These novel dihydrotriazinone-flavone hybrid compounds (7), their 2-methylchromenone analogs (8) and the L-proline homologs (9,10) were characterized by microanalytical and spectral (HRMS and NMR) data. Compounds 7a and 7i displayed good activity against (MCF-7) breast cancer.
