1402933-45-2Relevant academic research and scientific papers
Cinchona alkaloid and di-: Tert -butyldicarbonate-DMAP promoted efficient synthesis of (E)-nitroolefins
Poomathi, Nataraj,Perumal, Paramasivan T.
, p. 54495 - 54502 (2016)
The synthesis of nitroolefins from aldehydes and olefins is generally limited by the formation of a mixture of cis and trans compounds. Here we report an alternative, metal-free protocol for the synthesis of β-nitroolefins from arylidinemalononitrile using cinchona alkaloid along with di-tert-butyldicarbonate-DMAP in high yields with total selectivity.
Aqueous-mediated michael addition of active methylene compounds with nitroalkenes
Dong, Wenkai,Xu, Dongcheng,Xie, Jianwu
, p. 1771 - 1774 (2012/10/29)
A simple, atom economical and highly efficient green protocol has been developed for the synthesis of Michael adducts of nitroalkenes and 2-amino-2-chromene derivatives by Michael addition of active methylene compounds (such as malononitrile and ethyl cyanoacetate) to nitroalkenes under aqueous-mediated conditions. This green approach provided the desired products in high yields and the reaction scope proved to be quite broad.
