Carzinophilin, a natural antibiotic derived from a Streptomyces strain, was discovered in Japan in the 1950s. It exhibits strong antitumor potential and is a member of the bis-intercalator group of antibiotics. Carzinophilin acts by interlocking between the nucleotide bases of DNA, which may also contribute to its mutagenic activity. The molecule is composed of carbon, oxygen, hydrogen, and nitrogen, with its structure being elucidated in 1982.
1403-29-8
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Basic information
- Product Name: CARZINOPHILIN
- Synonyms: Antibiotic from streptomyces sahachiroi;Cardinophillin;Cardinophyllin;Carzinophyllin;Czp;Nsc20088
- CAS NO:1403-29-8
- Molecular Formula: C31H33N3O12
- Molecular Weight: 639.60662
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1403-29-8.mol
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Chemical Properties
- Melting Point: 219.5°C (rough estimate)
- Boiling Point: 671.87°C (rough estimate)
- Flash Point: 555.1°C
- Appearance: /
- Density: 1.3612 (rough estimate)
- Vapor Pressure: 0mmHg at 25°C
- Refractive Index: 1.7800 (estimate)
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: CARZINOPHILIN(CAS DataBase Reference)
- NIST Chemistry Reference: CARZINOPHILIN(1403-29-8)
- EPA Substance Registry System: CARZINOPHILIN(1403-29-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1403-29-8(Hazardous Substances Data)
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1403-29-8 Usage
Uses
Used in Anticancer Applications:Carzinophilin is used as an anticancer agent due to its strong antitumor potential. It targets and intercalates into DNA, disrupting the replication process and inhibiting tumor growth. However, its toxicity may limit its direct medical use, and further research is needed to optimize its application in cancer treatment.
Used in Research and Development:
Carzinophilin serves as a valuable compound in the field of research and development, particularly in the study of DNA interactions and the development of novel anticancer drugs. Its unique intercalating properties provide insights into the mechanisms of DNA-targeting agents and can potentially lead to the discovery of new therapeutic approaches.
Used in Drug Design and Development:
Carzinophilin's DNA intercalating properties make it a useful tool in drug design and development. Researchers can use its structure and mechanism of action as a starting point for designing new molecules with improved safety profiles and targeted antitumor effects. This may involve modifying the chemical structure to reduce toxicity while maintaining or enhancing its antitumor activity.
Check Digit Verification of cas no
The CAS Registry Mumber 1403-29-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,0 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.Calculate Digit Verification of CAS Registry Number 1403-29:
(6*1)+(5*4)+(4*0)+(3*3)+(2*2)+(1*9)=48
48 % 10 = 8
So 1403-29-8 is a valid CAS Registry Number.
InChI:InChI=1/C31H33N3O12/c1-14-7-6-8-18-19(14)9-17(43-5)10-20(18)26(40)32-13-30(4)24(39)28(41)45-31(46-30)25(23(38)22-11-34(22)16(3)37)44-27(33-29(31)42)21(12-35)15(2)36/h6-10,12,22-25,38-39H,11,13H2,1-5H3,(H,32,40)(H,33,42)/b27-21-
1403-29-8Upstream product
1403-29-8Downstream Products
- 93232-41-8 4-Bromo-benzoic acid (E)-2-(7-[(1-acetyl-aziridin-2-yl)-hydroxy-methyl]-3-hydroxy-2-{[(3-methoxy-5-methyl-naphthalene-1-carbonyl)-amino]-methyl}-2-methyl-4,11-dioxo-1,5,8-trioxa-10-aza-spiro[5.5]undec-9-en-9-yl)-3-oxo-but-1-enyl ester
- 93232-43-0 4-Bromo-benzoic acid (E)-2-(7-(2-acetylamino-1-hydroxy-propyl)-3-hydroxy-2-{[(3-methoxy-5-methyl-naphthalene-1-carbonyl)-amino]-methyl}-2-methyl-4,11-dioxo-1,5,8-trioxa-10-aza-spiro[5.5]undec-9-en-9-yl)-3-oxo-but-1-enyl ester
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CARZINOPHILIN
