1403-36-7 Usage
Uses
Used in Pharmaceutical Industry:
CHAETOMIN is used as an immunosuppressive agent for its ability to suppress the immune system. This property makes it a potential candidate for the treatment of various conditions where immune system modulation is required, such as autoimmune diseases or organ transplantation.
Used in Research Applications:
CHAETOMIN is also used in research settings to study the effects of immunosuppression on various biological processes and to develop new therapeutic strategies for immune-related disorders.
Biochem/physiol Actions
Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.
Check Digit Verification of cas no
The CAS Registry Mumber 1403-36-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,0 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1403-36:
(6*1)+(5*4)+(4*0)+(3*3)+(2*3)+(1*6)=47
47 % 10 = 7
So 1403-36-7 is a valid CAS Registry Number.
InChI:InChI=1/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32,38-39H,12,14-16H2,1-3H3/t22-,27+,28+,29+,30+,31+/m1/s1
