1403249-89-7Relevant academic research and scientific papers
2′-Modified Guanosine Analogs for the Treatment of HCV
Girijavallabhan, Vinay,Arasappan, Ashok,Bennett, Frank,Chen, Kevin,Dang, Qun,Huang, Ying,Kerekes, Angela,Nair, Latha,Pissarnitski, Dmitri,Verma, Vishal,Alvarez, Carmen,Chen, Ping,Cole, David,Esposite, Sara,Huang, Yuhua,Hong, Qingmei,Liu, Zhidan,Pan, Weidong,Pu, Haiyan,Rossman, Randall,Truong, Quang,Vibulbhan, Bancha,Wang, Jun,Zhao, Zhiqiang,Olsen, David,Stamford, Andrew,Bogen, Stephane,Njoroge, F. George
, p. 277 - 294 (2016)
Novel 2′-modified guanosine nucleosides were synthesized from inexpensive starting materials in 7–10 steps via hydroazidation or hydrocyanation reactions of the corresponding 2′-olefin. The antiviral effectiveness of the guanosine nucleosides was evaluated by converting them to the corresponding 5′-O-triphosphates (compounds 38–44) and testing their biochemical inhibitory activity against the wild-type NS5B polymerase.
2'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
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Paragraph 0265-0267, (2014/08/06)
The present invention relates to 2′-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Azido Substituted Nucleoside Derivative, and methods of using the 2′-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
2'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
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Page/Page column 74, (2012/11/06)
The present invention relates to 2'-Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, R1, R2 and R3 are as defined herein. The present invention also relates
