1403332-62-6 Usage
Property
Potent and selective inhibitor.
Target enzyme
MEK (Mitogen-Activated Protein Kinase Kinase).
Involvement in pathway
RAS-RAF-MEK-ERK signaling pathway.
Role in biological processes
Regulating cell growth and proliferation.
Mutations targeted
RAS or RAF gene mutations.
Therapeutic potential
Treatment of various types of cancer.
Current stage of development
Being studied in clinical trials.
Type of cancer targeted
Solid tumors, including melanoma and non-small cell lung cancer.
Potential use
Targeted therapy for cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 1403332-62-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,3,3,3 and 2 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1403332-62:
(9*1)+(8*4)+(7*0)+(6*3)+(5*3)+(4*3)+(3*2)+(2*6)+(1*2)=106
106 % 10 = 6
So 1403332-62-6 is a valid CAS Registry Number.
1403332-62-6Relevant articles and documents
PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
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Paragraph 0669-0672; 0673-0676, (2014/03/24)
The present invention relates to pyrazolyl-pyrimidine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
