1403333-94-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(cyclopropyl)-1H-pyrazole-3-carboxylic acid is used as a building block for the development of new drugs and bioactive molecules. Its unique structure and reactivity may contribute to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Chemical Research and Synthesis:
1-(cyclopropyl)-1H-pyrazole-3-carboxylic acid is used as a key intermediate in the synthesis of various chemical compounds. Its cyclopropyl group may offer unique reactivity and properties that can be utilized in the development of new synthetic routes and methodologies.

Upstream product

• 1403333-93-6 methyl 1-(cyclopropyl)-1H-pyrazole-3-carboxylate 

Downstream Products

• 1403333-92-5 (S)-N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-cyclopropyl-1H-pyrazole-3-carboxamide 
• 1403334-33-7 (S)-N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-cyclopropyl-1H-pyrazole-3-carboxamide 

Relevant academic research and scientific papers

SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

2-AMINO-6-METHYL-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL-1,3-THIAZOL-4-YL AMIDES

The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula (I), and the variable R1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

ANDROGEN RECEPTOR MODULATING CARBOXAMIDES

Compounds of formula (I) or (II) wherein Rx, Rz, R9, R10, R14, R14′, R15, R15′, A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.

ANDROGEN RECEPTOR MODULATING CARBOXAMIDES

Compounds of formula (I) wherein Rx, Rz, R9, R10, R14, R14', R15, R15', A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.