1403383-55-0Relevant articles and documents
Synthesis method of [...] process impurities (by machine translation)
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Paragraph 0019; 0020; 0021; 0022, (2018/07/07)
The invention discloses a method for synthesizing [...] process impurities, which belongs to the technical field of chemical pharmacy, to 4 - (4 - aminophenyl) morpholine - 3 - one (2), (S)- N - glycidol phthalimide (3) generating 2 - [(2 R) - 2 - hydroxy - 3 - [[4 - (3 - oxo - 4 - morpholinyl) phenyl] amino] propyl] - 1 H - isoindole - 1, 3 (2 H) - dione (4); compound (4) s hydrolysis, into salt generating (S)- 4 - (4 - ((3 - amino - 2 - hydroxy-propyl) aminophenyl) morpholine - 3 - one hydrochloride (5); compound (5) with 5 - chloro - 2 - acyl chloride thiophene (6) generating (S)- 5 - chloro - N - (3 - (5 - [...] - 2 - formyl amino) - 2 - hydroxy-propyl) - N - (4 - (3 - oxo-morpholino) phenyl) thiophene - 2 - carboxamide (1), to synthesize high-purity of [...][...] impurity can be used as a benefit finished product detection and analysis of the impurities in the standard, thereby improving the [...] finished product detection and analysis of the impurity and the accurate localization of the qualitative, conducive to strengthening the impurity of the control, and then [...] quality of the finished product, the present invention provides a method of cheap raw material, the operation is simple, the yield of product is 70% ± 5%, HPLC purity ≥ 98%. (by machine translation)