1403460-02-5Relevant articles and documents
Synthesis of substituted thiophenes by palladium-catalyzed heterocyclodehydration of 1-mercapto-3-yn-2-ols in conventional and nonconventional solvents
Gabriele, Bartolo,Mancuso, Raffaella,Veltri, Lucia,Maltese, Vito,Salerno, Giuseppe
, p. 9905 - 9909,5 (2012)
A variety of readily available 1-mercapto-3-yn-2-ols 5 were conveniently converted into the corresponding thiophenes 6 in good to high yields in MeOH as the solvent at 50-100 °C in the presence of catalytic amounts (1-2%) of PdI2 in conjunction with KI (KI:PdI2 molar ratio = 10). The catalyst could be made recyclable employing an ionic liquid, such as BmimBF4, as the solvent under suitable conditions.