1403495-52-2Relevant academic research and scientific papers
Palladium-catalyzed reaction of arylamine and diarylacetylene: Solvent-controlled construction of 2,3-diarylindoles and pentaarylpyrroles
Chen, Xiaopeng,Li, Xihui,Wang, Ningning,Jin, Jisong,Lu, Ping,Wang, Yanguang
experimental part, p. 4380 - 4386 (2012/09/21)
By choosing DMF and dioxane as solvent, skeletons of indoles and pyrroles were constructed from alkynes and amines in the presence of PdCl2, respectively. These Pd-catalyzed reactions were phosphane-free with high atom efficiency and could be conducted under mild basic conditions. The proposed mechanism for the selective formation of indoles and pyrroles in different solvents is also discussed in this paper. Two different kinds of Pd-catalyzed cyclizations, leading to the construction of 2,3-diarylindole and pentaarylpyrrole from the same alkyne and aniline starting materials, were approached by choosing different solvents. The mechanisms for these solvent-controlled reactions are proposed and discussed. Copyright
