14035-02-0

Basic information

• Product Name: 1-bromo-2-tert-butyl-4-methoxybenzene
• Synonyms: 1-bromo-2-tert-butyl-4-methoxybenzene
• CAS NO: 14035-02-0
• Molecular Weight: 243.143
• Mol File: 14035-02-0.mol

Chemical Properties

• CAS DataBase Reference: 1-bromo-2-tert-butyl-4-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-tert-butyl-4-methoxybenzene(14035-02-0)
• EPA Substance Registry System: 1-bromo-2-tert-butyl-4-methoxybenzene(14035-02-0)

Safety Data

• Hazardous Substances Data: 14035-02-0(Hazardous Substances Data)

Usage

Chemical structure

A benzene ring with a tert-butyl group and a methoxy group attached, and a bromine atom in the para position.

Common use

Organic synthesis and as a versatile building block for the preparation of various other organic compounds.

Industry applications

Pharmaceutical and agrochemical industries due to its strong aromatic and medicinal properties.

Reactivity

Unique structure and reactivity make it a key intermediate in the production of a wide variety of organic compounds and materials.

Hazardous nature

It may be hazardous to health and the environment if not properly managed and stored.

Safety precautions

Careful handling and proper storage are necessary to minimize risks associated with its potential hazards.

Upstream product

• 77-78-1 dimethyl sulfate 
• 33733-83-4 3-tert-butyl-1-methoxybenzene 

Downstream Products

• 103414-68-2 4-bromo-3-tret-butylphenol 
• 5530-41-6 5-Methoxy-3,3-dimethyl-indane 

Relevant articles and documents

Selective Halogenation Using an Aniline Catalyst

Electrophilic halogenation is used to produce a wide variety of halogenated compounds. Previously reported methods have been developed mainly using a reagent-based approach. Unfortunately, a suitable "catalytic" process for halogen transfer reactions has yet to be achieved. In this study, arylamines have been found to generate an N-halo arylamine intermediate, which acts as a highly reactive but selective catalytic electrophilic halogen source. A wide variety of heteroaromatic and aromatic compounds are halogenated using commercially available N-halosuccinimides, for example, NCS, NBS, and NIS, with good to excellent yields and with very high selectivity. In the case of unactivated double bonds, allylic chlorides are obtained under chlorination conditions, whereas bromocyclization occurs for polyolefin. The reactivity of the catalyst can be tuned by varying the electronic properties of the arene moiety of catalyst.

Synthesis of novel structurally simplified estrogen analogues with electron-donating groups in ring A

A library of 25 novel estrogen analogues were prepared in five to eight steps from mostly commercially available substituted anisoles via bromination, formylation, Corey-Fuchs reaction, elimination, and Sonogashira reaction. Georg Thieme Verlag Stuttgart.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 2 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

A Mild Selective Monobromination Reagent System for Alkoxybenzenes; N-Bromosuccinimide-Silica Gel

The monobromination of alkoxybenzenes with N-bromosuccinimide catalyzed by silica gel in carbon tetrachloride occurred preferentially at the para-position. m-t-Butylmethoxybenzene yielded 4-bromo-3-t-butyl-1-methoxybenzene with a selectivity of 74percent even in the presence of a bulky substituent at the meta-position.