14035-97-3Relevant academic research and scientific papers
Ketones as electrophile in nitroaldol reaction: Synthesis of β,β-disubstituted-1,3-dinitroalkanes and allylic nitro compounds
Costa, Jeronimo S.,Gomes, Alex O.,Pereira, Vera Lúcia P.,de Souza, Douglas L. F.
, p. 1575 - 1583 (2021/07/06)
β,β-Disubstituted-1,3-dinitro compounds were obtained exclusively with an overall yield of 83% through a domino nitroaldol/elimination/1,4-addition process, when excess nitromethane was added to cyclohexanone or butanone using DBU (1,8-diazabicyclo[5.4.0]
P(RNCH2CH2)3N: An Efficient Promoter for the Nitroaldol (Henry) Reaction
Kisanga, Philip B.,Verkade, John G.
, p. 4298 - 4303 (2007/10/03)
The use of catalytic amounts of the proazaphosphatranes P(MeNCH2CH2)3N, P(i-PrNCH2CH2)3N and P(HNCH2CH2)(i-PrNCH2CH2) 2N as nonionic bases in the reaction of nitroalkanes with carbonyl compounds is reported. The reaction proceeds at room temperature in the presence of 2.2 equiv of magnesium sulfate to produce the corresponding β-nitroalkanols in generally superior yields. Aldehydes react quantitatively in 5-60 min, whereas ketones require up to 3 h to react with nitromethane and up to 7 h for the reaction of ketones with higher nitroalkanes.
