1403506-76-2Relevant academic research and scientific papers
Enantioselective aza-Morita-Baylis-Hillman reactions of acrylonitrile catalyzed by palladium(II) pincer complexes having C2-symmetric chiral bis(imidazoline) ligands
Hyodo, Kengo,Nakamura, Shuichi,Shibata, Norio
supporting information, p. 10337 - 10341 (2012/11/13)
Simple and efficient: The first highly enantioselective aza-Morita-Baylis-Hillman reaction between acrylonitrile and imines has been developed. Excellent yields and enantioselectivities were observed for the reaction of various imines using chiral phebim/PdII complexes (1; see scheme). This process offers a simple and efficient route for the synthesis of functionalized α-methylene-β-aminonitriles and their derivatives. Copyright
