1403577-33-2Relevant academic research and scientific papers
Asymmetric synthesis of the fully elaborated pyrrolidinone core of oxazolomycin A
Donohoe, Timothy J.,O'Riordan, Timothy J. C.,Peifer, Manuel,Jones, Christopher R.,Miles, Timothy J.
, p. 5460 - 5463,4 (2012/12/12)
The asymmetric synthesis of the key pyrrolidinone core, including a highly elaborated exocyclic carbon chain, of the γ-lactam β-lactone antibiotic oxazolomycin A is described. Principal features include the Birch reduction of an aromatic pyrrole nucleus, a late stage RuO4 catalyzed pyrrolidine oxidation, and a highly diastereoselective organocerium addition to an aldehyde.
Asymmetric synthesis of the fully elaborated pyrrolidinone core of oxazolomycin A
Donohoe, Timothy J.,O'Riordan, Timothy J. C.,Peifer, Manuel,Jones, Christopher R.,Miles, Timothy J.
, p. 5460 - 5463 (2013/01/15)
The asymmetric synthesis of the key pyrrolidinone core, including a highly elaborated exocyclic carbon chain, of the γ-lactam β-lactone antibiotic oxazolomycin A is described. Principal features include the Birch reduction of an aromatic pyrrole nucleus, a late stage RuO4 catalyzed pyrrolidine oxidation, and a highly diastereoselective organocerium addition to an aldehyde.
