1403584-96-2

Upstream product

• 255828-69-4 (4S)-4-tert-butyl-1,3-thiazolidine-2-thione 
• 1403584-87-1 (8S,9R)-9,14,14,15,15-pentamethyl-8-vinyl-2,5,7,13-tetraoxa-14-silahexadecan-9-ol 
• 1403584-86-0 (8S,9S)-14,14,15,15-tetramethyl-8-vinyl-2,5,7,13-tetraoxa-14-silahexadecan-9-one 
• 1403584-85-9 (8S,9S)-14,14,15,15-tetramethyl-8-vinyl-2,5,7,13-tetraoxa-14-silahexadecan-9-ol 
• 1403584-89-3 3-((4R,5S)-2-(4-methoxyphenyl)-4-methyl-5-vinyl-1,3-dioxolan-4-yl)propanal 
• 255828-89-8 (S)-1-(4-(tert-butyl)-2-thioxothiazolidin-3-yl)ethan-1-one 
• 112245-13-3 (S)-tert-leucinol 

Downstream Products

• 1403584-90-6 (3R)-3-((tert-butyldimethylsilyl)oxy)-5-((4R,5S)-2-(4-methoxyphenyl)-4-methyl-5-vinyl-1,3-dioxolan-4-yl)pentanoic acid 
• 1419687-24-3 (3R)-1-((S)-4-(tert-butyl)-2-thioxothiazolidin-3-yl)-3-((tert-butyldimethylsilyl)oxy)-5-((4R,5S)-2-(4-methoxyphenyl)-4-methyl-5-vinyl-1,3-dioxolan-4-yl)pentan-1-one 
• 1403584-91-7 (3R)-(3S,4S,E)-1-iodo-2,4-dimethylhexa-1,5-dien-3-yl 3-((tert-butyldimethylsilyl)oxy)-5-((4R,5S)-2-(4-methoxyphenyl)-4-methyl-5-vinyl-1,3-dioxolan-4-yl)pentanoate 

Relevant academic research and scientific papers

SCALEABLE PREPARATION OF POLYKETIDES

Disclosed herein, inter alia, are methods of making polyketide compounds.

Structure of FD-895 revealed through total synthesis

The total synthesis of FD-895 was completed through a strategy that featured the use of a tandem esterification ring-closing metathesis (RCM) process to construct the 12-membered macrolide and a modified Stille coupling to append the side chain. These stu