1403656-83-6Relevant academic research and scientific papers
Regio- and stereoselective synthesis of polysubstituted 5-hydroxypyrrolidin-2-ones from 3-alkoxysuccinimides
da Silva, Fabio M.,da Silva, Andreia M.P.W.,Mittersteiner, Mateus,Andrade, Valquiria P.,da C. Aquino, Estefania,Bonacorso, Helio G.,Martins, Marcos A.P.,Zanatta, Nilo
, (2020)
The synthesis of 4-ethoxy-5-hydroxypyrrolidin-2-ones and 6-hydroxyhexahydro-4H-furo[2,3-c]pyrrol-4-ones — through the regio- and stereoselective reduction of the corresponding 3-alkoxysuccinimides — is described. The reaction used NaBH4 at low temperatures and short reaction times, providing products with yields of up to 77%. The stereoselectivity was highly influenced by both alkoxy and the N-moiety in the starting succinimide.
An efficient synthesis of 3-ethoxypyrrolidine-2,5-diones and cis-2,3,3a,6a-tetrahydrofuro[2,3-c]pyrrole-4,6(5H)-diones from β-cyanocarboxylic acids
Zanatta, Nilo,Da Silva, Fabio M.,Da Silva, Andreia M.P.W.,Da C. Aquino, Estefania,Bonacorso, Helio G.,Martins, Marcos A.P.
, p. 1 - 12 (2012/10/29)
A simple and convenient procedure for the synthesis of a new series of 3-ethoxypyrrolidine-2,5-diones and cis-2,3,3a,6a-tetrahydrofuro[2,3-c]pyrrole-4, 6(5H)-diones derivatives is described. All compounds were obtained from the direct cyclization of two β-cyanocarboxylic acids with primary amines and amino alcohols in short reaction time and good yields. ARKAT-USA, Inc.
