1403657-37-3Relevant articles and documents
Peculiarities of the tandem reaction between cyanoacetylenic alcohols and aminobenzoic acids: Synthesis of 5,5-dialkyl-2-(3-aminophenyl)-4-oxo-4,5- dihydrofuran-3-carbonitriles
Shemyakina, Olesya A.,Mal'kina, Anastasiya G.,Nosyreva, Valentina V.,Ushakov, Igor A.,Trofimov, Boris A.
, p. 319 - 325 (2012/11/07)
Tertiary cyanoacetylenic alcohols 1 reacting with 3-aminobenzoic acid (Et3N, MeCN, 20-25 °C, 28-30 h) afforded 5,5-dialkyl-2-(3- aminophenyl)-4-oxo-4,5-dihydrofuran-3-carbonitriles 2 (77-85%). Under the same condition, 4-hydroxy-4-methylpent-2-