1403665-72-4Relevant academic research and scientific papers
Structural diversity of new C13-polyketides produced by Chaetomium mollipilium cultivated in the presence of a NAD+-dependent histone deacetylase inhibitor
Asai, Teigo,Morita, Shuntaro,Shirata, Naoki,Taniguchi, Tohru,Monde, Kenji,Sakurai, Hiroaki,Ozeki, Tomoji,Oshima, Yoshiteru
, p. 5456 - 5459 (2012)
Cultivation of Chaetomium mollipilium with nicotinamide, a NAD +-dependent HDAC inhibitor, stimulated its secondary metabolism, leading to the isolation of structurally diverse new C13-polyketides, mollipilin A-E (1-5) as well as two known compounds (6 and 7). Spectroscopic methods, X-ray single crystal diffraction analysis, and VCD elucidated the absolute configurations of structures 1-6, and plausible biosynthetic pathways for 1-7 were proposed based on structural relationships. Mollipilins A (1) and B (2) exhibited moderate growth inhibitory effects on HCT-116 cells.
