1403669-00-0

Basic information

• Product Name: C₁₅H₁₈N₄O₂
• CAS NO: 1403669-00-0
• Molecular Weight: 286.334
• Mol File: 1403669-00-0.mol

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₈N₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₈N₄O₂(1403669-00-0)
• EPA Substance Registry System: C₁₅H₁₈N₄O₂(1403669-00-0)

Safety Data

• Hazardous Substances Data: 1403669-00-0(Hazardous Substances Data)

Upstream product

• 1403669-20-4 4-(4-chloro-6-((4-methoxybenzyl)oxy)pyrimidin-2-yl)morpholine 

Relevant articles and documents

Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one- containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation

The discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2- one-containing inhibitors of Phosphoinositide 3-kinases (PI3K) p110β isoform is reported. Structure-based optimisation of the original fragment hit resulted in lead compounds with improvements in ligand efficiency, lipophilicity efficiency, p110β potency and selectivity over p110α.