1403680-52-3

Basic information

• Product Name: (4R,4aR,8aS)-methyl 8a-hydroxy-6-methyl-4a-nitro-4-phenyl-4a,5,6,7,8,8a-hexahydro-4H-chromene-2-carboxylate
• CAS NO: 1403680-52-3
• Molecular Weight: 347.368
• Mol File: 1403680-52-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4R,4aR,8aS)-methyl 8a-hydroxy-6-methyl-4a-nitro-4-phenyl-4a,5,6,7,8,8a-hexahydro-4H-chromene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,4aR,8aS)-methyl 8a-hydroxy-6-methyl-4a-nitro-4-phenyl-4a,5,6,7,8,8a-hexahydro-4H-chromene-2-carboxylate(1403680-52-3)
• EPA Substance Registry System: (4R,4aR,8aS)-methyl 8a-hydroxy-6-methyl-4a-nitro-4-phenyl-4a,5,6,7,8,8a-hexahydro-4H-chromene-2-carboxylate(1403680-52-3)

Safety Data

• Hazardous Substances Data: 1403680-52-3(Hazardous Substances Data)

Upstream product

• 107969-78-8 methyl 4-phenyl-2-oxo-3-butenoate 
• 81842-51-5 4-methyl-2-nitro-cyclohexanone 

Relevant articles and documents

Asymmetric inverse-electron-demand hetero-diels-alder reaction for the construction of bicyclic skeletons with multiple stereocenters by using a bifunctional organocatalytic strategy: An efficient approach to chiral macrolides

We have performed the first bifunctional organocatalytic highly enantioselective inverse-electron-demand hetero-Diels-Alder reaction of cyclic ketones with enones to afford densely functionalized bicyclic skeletons that contain three stereocenters (up 82 % yield, 10:1 d.r., and 97 % ee). Unlike the previous IEDDAR catalytic strategy, this method features a double HOMO dienophile/ LUMOdiene-activated pathway. Moreover, this process provides a promising method for the construction of enantioenriched macrolides. Bicyclic exercises: A highly enantioselective inverse-electron- demand hetero-Diels-Alder reaction of cyclic ketones with enones affords functionalized bicyclic skeletons with three stereocenters that can be used for the construction of macrolides. Copyright