140371-97-7Relevant academic research and scientific papers
NOVEL OPTICALLY ACTIVE COMPOUNDS, METHOD FOR KINETIC OPTICAL RESOLUTION OF CARBOXYLIC ACID DERIVATIVES AND CATALYSTS THEREFOR
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Page 19; 23; 25, (2008/06/13)
The present invention provides a method of kinetic optical resolution of carboxylic acid derivatives using specific optically active catalysts. A racemic or diastereomeric mixture of carboxylic acid derivatives of the formula (A) is reacted with a nucleophile in the presence of an optically active catalyst to form an optically active nucleophile derivative of the formula (B). The catalyst is an optically active compound represented by the formula (C) or (D) [wherein R1 is a substituted or unsubstituted, saturated or unsaturated, straight-chain, branched or alicyclic aliphatic hydrocarbon group which can have a heteroatom, R2 is ethyl or vinyl, and R5 is hydrogen or methoxy respectively].
ANGIOTENSIN CONVERTING ENZYME INHIBITORS
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, (2008/06/13)
Angiotensin converting enzyme inhibitors have the formula Z(CH. sub.2). sub.n CHR 1 COOCHR 2 COOHin which Z is--SR. sub. 3,--COCHR 4 NHCOR 5, STR1 or--NHCHR 7 COOH, R. sub.4, R. sub.5, R 6, and R 7, which may be the same or different, are each phenyl or alkylphenyl C 7-12,R 4 is hydrogen, alkyl C 1-6, NHR 8 or (CH 2) p R 9, R 2 is (CH 2) m XR 10, alkyl C 1-6 optionally substituted by a saturated 5-or 6-membered carbocyclic or heterocyclic ring, alkylhalo C 1-6, alkylcyano C 1-6, or alkyl phenyl C 7-12, the phenyl being optionally substituted by NO 2 or NH 2,X is O, S(O) q, C=O or NR 11, andR 10 is alkyl C 1-6, alkylhalo C 1-6, alkoxy C 1-6, alkoxy C 1-6 substituted by halogen, alkanoyl C 1-6, S(O) r R. sub.12, NR 13 R 14, phenyl, alkylphenyl C 7-12, naphthalenyl or a 5-membered unsaturated heterocyclic ring, n is an integer from 0 to 6,m and p, which may be the same or different, are each an integer from 1 to 6,R 9 is hydrogen, SR 15 or phenyl optionally substituted by OR 16,R 3 and R 15, which may be the same or different, are each hydrogen or alkanoyl C 1-6,R. sub.8 is hydrogen or COOR 17,q and r, which may be the same or different, are each 0, 1, or 2,R 11, R. sub.13, R. sub.14, R 16, and R 17, which may be the same or different, are each hydrogen or alkyl C 1-6, and R 12 is hydrogen, alkyl C 1-6 or phenyl.The compounds, and salts thereof, are useful as vasodilators.
