1403749-43-8

Basic information

• Product Name: (R)-ethyl 2-fluoro-4-phenylbutanoate
• Synonyms: (R)-ethyl 2-fluoro-4-phenylbutanoate
• CAS NO: 1403749-43-8
• Molecular Weight: 210.248
• Mol File: 1403749-43-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-ethyl 2-fluoro-4-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ethyl 2-fluoro-4-phenylbutanoate(1403749-43-8)
• EPA Substance Registry System: (R)-ethyl 2-fluoro-4-phenylbutanoate(1403749-43-8)

Safety Data

• Hazardous Substances Data: 1403749-43-8(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 1378834-52-6 2-chloro-4-phenylbutyraldehyde 
• 1403749-37-0 (R,E)-ethyl 2-fluoro-4-phenylbut-3-enoate 

Relevant articles and documents

N-heterocyclic carbene catalyzed enantioselective α-fluorination of aliphatic aldehydes and α-chloro aldehydes: Synthesis of α-fluoro esters, amides, and thioesters

The asymmetric fluorination of azolium enolates that are generated from readily available simple aliphatic aldehydes or α-chloro aldehydes and N-heterocyclic carbenes (NHCs) is described. The process significantly expands the synthetic utility of NHC-catalyzed fluorination and provides facile access to a wide range of α-fluoro esters, amides, and thioesters with excellent enantioselectivity. Pyrazole was identified as an excellent acyl transfer reagent for catalytic amide formation.