140377-95-3Relevant academic research and scientific papers
Biogentic amine uptake inhibitors
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, (2008/06/13)
Compounds of the formula: STR1 or a pharmaceutically acceptable salt thereof, wherein m is 0, 1 or 2 and n is 0 or 1; R1 is hydrogen or lower alkyl; R2 is C1 -C6 -alkyl substituted with a heterocyclic group or C7 -C16 -arylalkyl, wherein the aryl group is unsubstituted or substituted with from one to three non-hydrogen members independently selected from the group consisting of halogen, C1 -C6 -alkyl, halo-C1 -C6 -alkyl, C1 -C6 -alkoxy, hydroxy, amino and C1 -C6 -alkylamino; R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen, C1 -C6 -alkoxy, C1 -C6 -alkyl, halogen, and halo-C1 -C6 -alkyl, or any two of R3, R4, R5 and R6 taken together form a methylenedioxy group; and R7 is hydrogen or C1 -C6 -alkyl. These compounds are useful as inhibitors of the neuronal uptake of biogenic amines and for the treatment of affective disorders, such as, for example, depression.
