1403776-09-9

Basic information

• Product Name: C₂₀H₂₅N₃O₂
• CAS NO: 1403776-09-9
• Molecular Weight: 339.437
• Mol File: 1403776-09-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₅N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₅N₃O₂(1403776-09-9)
• EPA Substance Registry System: C₂₀H₂₅N₃O₂(1403776-09-9)

Safety Data

• Hazardous Substances Data: 1403776-09-9(Hazardous Substances Data)

Upstream product

• 1403775-97-2 C₁₂H₁₃N₃O*ClH 
• 768397-75-7 3-methylcyclohexanecarbonyl chloride 
• 1403775-95-0 C₁₇H₂₁N₃O₃ 
• 13293-59-9 3-methylcyclohexanecarboxylic acid 

Relevant articles and documents

Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators

A novel series of aryl azetidinyl oxadiazoles are identified as mGluR5 positive allosteric modulators (PAMs) with improved physico-chemical properties. N-substituted cyclohexyl and exo-norbornyl carboxamides, and carbamate analogs of azetidines are moderate to potent mGluR5 PAMs. The aryl, lower alkyl carboxamides analogs and sulfonamide analogs of azetidines are moderate mGluR5 negative allosteric modulators (NAMs). In the aryl oxadiazole moiety, substituents such as fluoro, chloro and methyl are well tolerated at the meta position while para substituents led to either inactive compounds or NAMs. A tight pharmacophore and subtle 'PAM to NAM switching' with close analogs makes the optimization of the series extremely challenging.