1403783-46-9

Upstream product

• 931-51-1 cyclohexylmagnesiumchloride 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 87482-75-5 1-(4-chlorophenyl)-2-cyclohexylethan-1-one 
• 1712-70-5 1-chloro-4-(1-methylethenyl)-benzene 
• 4441-56-9 cyclohexylboronic acid 

Downstream Products

• 1403783-44-7 2-(4-(2-(4-chlorophenyl)-2-(cyclohexylmethyl)-1-(4-methoxyphenyl)-cyclopropyl)phenoxy)-N,N-dimethylethanamine 

Relevant academic research and scientific papers

Visible-Light-Mediated Alkenylation of Alkyl Boronic Acids without an External Lewis Base as an Activator

Herein we report a protocol for the direct visible-light-mediated alkenylation of alkyl boronic acids at room temperature without an external Lewis base as an activator, and we propose a mechanism involving benzenesulfinate activation of the alkyl boronic acids. The protocol permits the efficient functionalization of a broad range of cyclic and acyclic primary and secondary alkyl boronic acids with various alkenyl sulfones. We demonstrated its utility by preparing or functionalizing several pharmaceuticals and natural products.

Synthesis on novel Tamoxifen derivatives

The design and synthesis of derivatives of 4-hydroxy-Tamoxifen as potential antagonists of the nuclear receptor LRH-1 are described. Stereoselective McMurry coupling was used to generate the desired internal alkene and a novel method for the synthesis of