140382-04-3

Basic information

• Product Name: Acetamide, 2,2,2-trichloro-N-[1-(hydroxymethyl)pentyl]-, (R)-
• CAS NO: 140382-04-3
• Molecular Formula: C8H14Cl3NO2
• Molecular Weight: 262.564
• Mol File: 140382-04-3.mol

Chemical Properties

• CAS DataBase Reference: Acetamide, 2,2,2-trichloro-N-[1-(hydroxymethyl)pentyl]-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2,2,2-trichloro-N-[1-(hydroxymethyl)pentyl]-, (R)-(140382-04-3)
• EPA Substance Registry System: Acetamide, 2,2,2-trichloro-N-[1-(hydroxymethyl)pentyl]-, (R)-(140382-04-3)

Safety Data

• Hazardous Substances Data: 140382-04-3(Hazardous Substances Data)

Upstream product

• 140382-01-0 N-<(E)-(3R,4'S)-1-(2,2-dimethyl-1,3-dioxolane-4-yl)-hept-1-en-3-yl>-2,2,2-trichloroacetamide 

Relevant articles and documents

On the palladium(II)-catalyzed rearrangement of allyl imidates

Polyhetero-[3,3]-sigmatropic rearrangements of allyl N-phenylimidates 4a-f catalyzed by dichlorobis-(benzonitrile)palladium(II) are shown to afford N-allyl-N-phenylamides in good to excellent yields for substitution patterns that have so far precluded cyclization-induced allyl shifts. Using trichloroacetimidates of secondary allyl alcohols as substrates, the palladium(II)-catalyst effects a completely (E) stereoselective rearrangement at room temperature which proceeds with complete chirality transfer. This reaction has been applied to a synthesis of (R)-N-(trichloroacetyl)norleucinol (18) starting from (R)-2,3-O-isopropylideneglyceraldehyde (17).