1403834-84-3Relevant academic research and scientific papers
Trimethoxyphenylthio as a highly labile replacement for tert-butylthio cysteine protection in fmoc solid phase synthesis
Postma, Tobias M.,Albericio, Fernando,Giraud, Matthieu
, p. 5468 - 5471,4 (2012)
Trimethoxyphenylthio (S-Tmp) is described as a novel cysteine protecting group in Fmoc solid phase peptide synthesis replacing the difficult to remove tert-butylthio. S-Tmp and dimethoxyphenylthio (S-Dmp) were successfully used for cysteine protection in a variety of peptides. Moreover, both groups can be removed in 5 min with mild reducing agents. S-Tmp is recommended for cysteine protection, as it yields crude peptides of high purity.
Trimethoxyphenylthio as a highly labile replacement for tert-butylthio cysteine protection in fmoc solid phase synthesis
Postma, Tobias M.,Giraud, Matthieu,Albericio, Fernando
supporting information, p. 5468 - 5471 (2013/01/15)
Trimethoxyphenylthio (S-Tmp) is described as a novel cysteine protecting group in Fmoc solid phase peptide synthesis replacing the difficult to remove tert-butylthio. S-Tmp and dimethoxyphenylthio (S-Dmp) were successfully used for cysteine protection in a variety of peptides. Moreover, both groups can be removed in 5 min with mild reducing agents. S-Tmp is recommended for cysteine protection, as it yields crude peptides of high purity.
