1403835-75-5Relevant academic research and scientific papers
Synthesis of 3-iodothiophenes via iodocyclization of (Z)-thiobutenynes
Santana, Amanda S.,Carvalho, Diego B.,Cassemiro, Nadla S.,Viana, Luiz H.,Hurtado, Gabriela R.,Amaral, Marcos S.,Kassab, Najla M.,Guerrero Jr., Palimécio G.,Barbosa, Sandro L.,Dabdoub, Miguel J.,Baroni, Adriano C.M.
supporting information, p. 52 - 55 (2014/01/06)
A simple synthesis of 3-iodothiophenes was demonstrated using a wide range of (Z)-thioenynes. The key step in the iodocyclofunctionalization was the selective reduction of the triple bond in (Z)-thioenynes by the addition of iodine as an electrophilic age
Improvement in the synthesis of (Z)-organylthioenynes via hydrothiolation of buta-1,3-diynes: A comparative study using NaOH or TBAOH as base
Santana, Amanda S.,Carvalho, Diego B.,Casemiro, Nadla S.,Hurtado, Gabriela R.,Viana, Luiz H.,Kassab, Nájla M.,Barbosa, Sandro L.,Marques, Francisco A.,Guerrero Jr., Palimécio G.,Baroni, Adriano C.M.
, p. 5733 - 5738 (2012/10/30)
Hydrothiolation of symmetrical and unsymmetrical buta-1,3-diynes with sodium organylthiolate anions in reflux, generated in situ by reacting C 4H9SH with NaOH, afforded (Z)-organylthioenynes in low to good yields (25-80%). By using tetrabutylammonium hydroxide (TBAOH) as base instead of NaOH, the hydrothiolation of buta-1,3-diynes was more rapid and efficient, providing (Z)-organylthioenynes in good to excellent yields (70-95%).
