140384-88-9Relevant academic research and scientific papers
Synthesis and pharmacological investigation of new chiral muscarinic antagonists
Carnielli,De Amici,De Micheli,Gianferrara,Maurich,Zacchigna,Grana,Boselli
, p. 21 - 27 (2007/10/02)
The two pairs of enantiomers of isoxazolidin-3-ones 3 and 4 were synthesized by means of Lipase PS-catalyzed hydrolyses of suitable racemic butyrates. The same butyrates were also employed as key intermediates in the preparation of racemic 3 and 4. The an
Nitrile Oxides in Medicinal Chemistry. 4. Chemoenzymatic Synthesis of Chiral Heterocyclic Derivatives
Amici, Marco De,Magri, Paolo,Micheli, Carlo De,Cateni, Francesca,Bovara, Roberto,et al.
, p. 2825 - 2829 (2007/10/02)
The two enantiomers of 3-bromo-5-(hydroxymethyl)-Δ2-isoxazoline (1) and 2-phenyl-5-(hydroxymethyl)-isoxazolidin-3-one (9) have been prepared in enantiomeric excess higher than 90percent by hydrolysis of the corresponding butyrates under the cat
