1403884-76-3Relevant academic research and scientific papers
Phenylboronic acid as efficient and eco-friendly catalyst for the one-pot, three-component synthesis of α-aminophosphonates under solvent-free conditions
Tibhe, Gaurao D.,Bedolla-Medrano, Mercedes,Cativiela, Carlos,Ordó?ez, Mario
, p. 1931 - 1936 (2012)
A simple, mild, and efficient one-pot, three-component synthetic method has been developed for the preparation of α-aminophosphonates using phenylboronic acid as catalyst under solvent-free conditions at 50°C. The process involves the reaction of carbonyl compounds (aldehydes or ketones) with benzylamine and dimethyl phosphite. A wide range of carbonyl compounds are compatible with this reaction, producing tertiary and quaternary α-aminophosphonates in moderated to excellent yields in short time. Georg Thieme Verlag Stuttgart · New York.
Phenylphosphonic acid as efficient and recyclable catalyst in the synthesis of α-aminophosphonates under solvent-free conditions
Bedolla-Medrano, Mercedes,Hernández-Fernández, Eugenio,Ordó?ez, Mario
, p. 1145 - 1149 (2014/05/20)
Phenylphosphonic acid is an efficient, friendly and reusable heterogeneous catalyst for the synthesis of α-aminophosphonates through a 'one-pot' three-component reaction of amines, carbonyl compounds and dialkyl phosphites under solvent-free conditions. This methodology illustrates a very simple procedure, with wide applicability, extending the scope to aliphatic and aromatic amines, aliphatic and aromatic aldehydes and aliphatic ketones. It also enabled the synthesis of α-aminophosphonates in large scale, clean conversion, easy workup and purification. Excellent results were obtained in each case obtaining the desire compounds in moderate to good yields. Georg Thieme Verlag Stuttgart New York.
