1404-15-5

Basic information

• Product Name: NOGALAMYCIN
• Synonyms: antibioticnsc70845;nogalomycin;nsc-70845;NOGALAMYCIN, STREPTOMYCES NOGALATER;NOGALAMYCIN;NOGALAMYCIN FROM STREPTOMYCES NOGALATER;AIDS031122;Nogalamycin >=95%, from Streptomyces nogalater
• CAS NO: 1404-15-5
• Molecular Formula: C39H49NO16
• Molecular Weight: 787.8
• Product Categories: Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Inhibits an EnzymeAntibiotics;Interferes with DNA Synthesis;Mechanism of Action
• Mol File: 1404-15-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 195-196° (dec)
• Boiling Point: 658.61°C (rough estimate)
• Flash Point: 498.1°C
• Appearance: /
• Density: 1.2095 (rough estimate)
• Vapor Pressure: 7.49E-35mmHg at 25°C
• Refractive Index: 1.7650 (estimate)
• Storage Temp.: 2-8°C
• PKA: 7.45 (60% ethanol)
• CAS DataBase Reference: NOGALAMYCIN(CAS DataBase Reference)
• NIST Chemistry Reference: NOGALAMYCIN(1404-15-5)
• EPA Substance Registry System: NOGALAMYCIN(1404-15-5)

Safety Data

• Hazard Codes: T
• Statements: 45-46-61-20/21/22
• Safety Statements: 53-22-36/37/39-45
• WGK Germany: 3
• RTECS: RA4550000
• Hazardous Substances Data: 1404-15-5(Hazardous Substances Data)

Usage

Description

Nogalamycin, produced by Streptomyces nogalater var. nogalater, is an unusual anthracycline antibiotic with potent antibacterial and antitumor properties. It is characterized by its unique structure, which includes two saccharides attached to the D and A rings, forming a distinct family of hexacyclic anthracyclines. Nogalamycin interacts with DNA through intercalation, making it a significant compound in the field of medicine.

Uses

Used in Pharmaceutical Industry:
Nogalamycin is used as an antitumor agent for its potent activity against various types of cancer. It modulates oncological signaling pathways and demonstrates synergistic effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
Used in Organic Synthesis:
Nogalamycin (CAS# 1404-15-5) is utilized as a compound in organic synthesis, contributing to the development of new pharmaceuticals and chemical compounds with potential applications in various industries.

Biochem/physiol Actions

Anthracyclic antitumor antibiotic.

Safety Profile

Poison by intravenous andintraperitoneal routes. Human mutation data reported. Anantibiotic. When heated to decomposition it emits toxicfumes of NOx.

InChI:InChI=1/C39H49NO16/c1-14-32(49-7)39(4,52-10)33(50-8)36(53-14)54-19-13-37(2,48)24(34(47)51-9)15-11-16-21(27(43)20(15)19)28(44)22-18(41)12-17-30(23(22)26(16)42)55-35-29(45)25(40(5)6)31(46)38(17,3)56-35/h11-12,14,19,24-25,29,31-33,35-36,41,43,45-46,48H,13H2,1-10H3/t14?,19-,24-,25-,29-,31+,32?,33?,35-,36?,37-,38-,39?/m0/s1

Related news

Voltammetric studies of the interaction of NOGALAMYCIN (cas 1404-15-5) antitumor drug with DNA09/06/2019

The interaction of nogalamycin (NOM), an anthracycline antitumor drug, with calf thymus DNA has been studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The variations in the cyclic voltammetric behaviour of NOM on addition of DNA have been carried out. The experimental ...detailed

The biochemical pharmacology of NOGALAMYCIN (cas 1404-15-5) and its derivatives☆09/04/2019

This review assimilates up-to-date information on the biochemical pharmacology of nogalamycin and selected derivatives that have shown good biological activities and/or received a relatively detailed investigation. The structure and chemical preparation of these derivatives from nogalamycin is d...detailed

ArticleDiscovery of a Two-Component Monooxygenase SnoaW/SnoaL2 Involved in NOGALAMYCIN (cas 1404-15-5) Biosynthesis09/03/2019

SummaryNogalamycin is an anthracycline polyketide antibiotic that contains two deoxysugars, at positions C-1 and C-7. Previous biosynthetic studies conducted in vivo affiliated snoaL2 with an unusual C-1 hydroxylation reaction, but in vitro activity was not established. Here, we demonstrate that...detailed

Construction of the DEF-ring system of NOGALAMYCIN (cas 1404-15-5) and menogaril via an efficient Suzuki-Miyaura reaction09/02/2019

A new approach to the total synthesis of anthracycline natural products, nogalamycin and menogaril, was explored. The goal was to enable late-stage introduction of the EF-ring segment. The new synthetic route has been developed through strategic application of a Suzuki-Miyaura reaction as the ke...detailed