1404093-41-9Relevant academic research and scientific papers
Magnetically separable CuFe2O4 nanoparticles as a recoverable catalyst for the addition reaction of C(sp3)-H bond of azaarenes to aldehydes
Wang, Zu-Li
, p. 5563 - 5566 (2015)
A green and efficient protocol for the copper ferrite (CuFe2O4) nanoparticle-catalyzed direct C(sp3)-H bond functionalization of 2-alkyl azaarenes has been developed. The magnetic catalyst can be recovered and recycled by a simple magnetic separation from the reaction solution and reused eight times without significant decrease in catalytic activity. This journal is
A synthesis method of pyridine and quinoline derivatives
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Paragraph 0047-0050, (2017/02/28)
The invention discloses a method for synthesizing pyridine and quinoline derivative. The method for synthesizing the pyridine and quinoline derivative comprises the following steps: heating and carrying out reaction on a pyridine or quinoline compound A and an aldehyde compound B in an ionic liquid [Bmim]BF4, wherein an ionic liquid [Hnhm]HSO4 is taken as a catalyst, and pyridine and quinoline derivative C can be obtained after reaction is carried out for a period of time. The catalyst [Hmim]H2PO4 and the solvent [Bmim]BF4 which are used in the reaction can be recycled and utilized for eight times, and yield of a final product is not obviously reduced; therefore, the method for synthesizing the pyridine and quinoline derivative can reduce experimental cost to the utmost extent and reduce environmental pollution and has a good application prospect. The reaction formula is described in the specification.
Acid ionic liquid promoted addition of C(sp3)-H bond to aldehyde
Zhang, Xue-Yan,Dong, Dao-Qing,Yue, Tao,Hao, Shuang-Hong,Wang, Zu-Li
supporting information, p. 5462 - 5464 (2014/12/11)
A novel protocol for acid ionic liquid promoted C(sp3)-H bond functionalization of alkyl azaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields, which provides an efficient approach for the synthesis of alkyl-substituted azaarene derivatives. It is worthwhile to note that acid ionic liquid used for this reaction can be recycled and reused six times without a significant decrease in activity.
Bronsted acid promoted benzylic C-H bond functionalization of azaarenes: Nucleophilic addition to aldehydes
Wang, Fang-Fang,Luo, Cui-Ping,Wang, Yi,Deng, Guojun,Yang, Luo
supporting information, p. 8605 - 8608 (2013/01/15)
A practical Bronsted acid promoted benzylic C-H functionalization of 2-methylazaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields. A six-membered hydrogen-bonding transition state is proposed to be crucial for the reaction. Ready availability of the two starting materials, the use of acetic acid as the catalyst and the facile reaction conditions will guarantee this synthetic method attractive to the synthesis of bioactive pyridine and quinoline derivatives.
