1404093-45-3Relevant academic research and scientific papers
α-Chymotrypsin–catalyzed direct C (Sp3)–H functionalization reactions for synthesis of azaarene derivatives in water
Le, Zhang-Gao,Lu, Yue,Jiang, Guo-Fang,Liu, Yi-Shuai,Liu, Jia,Xie, Zong-Bo
, p. 3135 - 3144 (2019)
α-Chymotrypsin from the bovine pancreas has been shown for the first time to display catalytic nonnatural catalytic ability toward the C (sp3)–H functionalization reaction of 2-methylquinoline and aromatic aldehydes in water. α-Chymotrypsin exhibited favorable catalytic activity with good adaptability to different substrates. The activity of the enzyme could be improved by adjusting the solvent, temperature, molar ratio of substrates, and protein loading. The products were obtained in moderate to excellent yields (51%-93%) in 24 samples. This process afforded a potential biocatalytic approach as an alternative to chemical synthesis for azaarene derivatives.
Magnetically separable CuFe2O4 nanoparticles as a recoverable catalyst for the addition reaction of C(sp3)-H bond of azaarenes to aldehydes
Wang, Zu-Li
, p. 5563 - 5566 (2015/03/05)
A green and efficient protocol for the copper ferrite (CuFe2O4) nanoparticle-catalyzed direct C(sp3)-H bond functionalization of 2-alkyl azaarenes has been developed. The magnetic catalyst can be recovered and recycled by a simple magnetic separation from the reaction solution and reused eight times without significant decrease in catalytic activity. This journal is
Acid ionic liquid promoted addition of C(sp3)-H bond to aldehyde
Zhang, Xue-Yan,Dong, Dao-Qing,Yue, Tao,Hao, Shuang-Hong,Wang, Zu-Li
supporting information, p. 5462 - 5464 (2014/12/11)
A novel protocol for acid ionic liquid promoted C(sp3)-H bond functionalization of alkyl azaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields, which provides an efficient approach for the synthesis of alkyl-substituted azaarene derivatives. It is worthwhile to note that acid ionic liquid used for this reaction can be recycled and reused six times without a significant decrease in activity.
Bronsted acid promoted benzylic C-H bond functionalization of azaarenes: Nucleophilic addition to aldehydes
Wang, Fang-Fang,Luo, Cui-Ping,Wang, Yi,Deng, Guojun,Yang, Luo
supporting information, p. 8605 - 8608 (2013/01/15)
A practical Bronsted acid promoted benzylic C-H functionalization of 2-methylazaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields. A six-membered hydrogen-bonding transition state is proposed to be crucial for the reaction. Ready availability of the two starting materials, the use of acetic acid as the catalyst and the facile reaction conditions will guarantee this synthetic method attractive to the synthesis of bioactive pyridine and quinoline derivatives.
