1404093-61-3

Basic information

• Product Name: C₂₉H₂₉BrN₄O₄
• Synonyms: C₂₉H₂₉BrN₄O₄
• CAS NO: 1404093-61-3
• Molecular Weight: 577.478
• Mol File: 1404093-61-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₂₉BrN₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₂₉BrN₄O₄(1404093-61-3)
• EPA Substance Registry System: C₂₉H₂₉BrN₄O₄(1404093-61-3)

Safety Data

• Hazardous Substances Data: 1404093-61-3(Hazardous Substances Data)

Upstream product

• 655254-61-8 1-bromo-4-(isocyano(tosyl)methyl)benzene 
• 362670-09-5 (2-amino-5-methoxyphenyl)carbamate tert-butyl ester 

Downstream Products

• 1404093-64-6 C₁₇H₁₃BrN₄O 

Relevant articles and documents

A Van Leusen deprotection-cyclization strategy as a fast entry into two imidazoquinoxaline families

A concise synthesis of two pharmacologically relevant classes of molecules possessing the imidazoquinoxaline core is reported. The protocol involves use of 1,2-phenylenediamines and glyoxylic acid derivatives, namely ethyl glyoxylate or benzylglyoxamide, along with tosylmethylisocyanides in a microwave-assisted Van Leusen three-component condensation. Subsequent unmasking (Boc removal) of an internal amino-nucleophile promotes deprotection and cyclization that take place either spontaneously in a one-pot fashion to give 8 or upon acidic treatment under microwave irradiation after isolation of the imidazole intermediate to give 11. Of note, a tricyclic framework is hence assembled by means of a rapid and straightforward method with a high bond-forming efficiency.