1404095-27-7Relevant academic research and scientific papers
Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors
Lainchbury, Michael,Matthews, Thomas P.,McHardy, Tatiana,Boxall, Kathy J.,Walton, Michael I.,Eve, Paul D.,Hayes, Angela,Valenti, Melanie R.,De Haven Brandon, Alexis K.,Box, Gary,Aherne, G. Wynne,Reader, John C.,Raynaud, Florence I.,Eccles, Suzanne A.,Garrett, Michelle D.,Collins, Ian
, p. 10229 - 10240 (2013/01/16)
Inhibitors of checkpoint kinase 1 (CHK1) are of current interest as potential antitumor agents, but the most advanced inhibitor series reported to date are not orally bioavailable. A novel series of potent and orally bioavailable 3-alkoxyamino-5-(pyridin-
