14041-87-3

Basic information

• Product Name: N,N'-DICYCLOHEXYLSULFAMIDE
• Synonyms: N,N'-DICYCLOHEXYLSULFAMIDE
• CAS NO: 14041-87-3
• Molecular Formula: C₁₂H₂₄N₂O₂S
• Molecular Weight: 260.4
• Mol File: 14041-87-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N,N'-DICYCLOHEXYLSULFAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-DICYCLOHEXYLSULFAMIDE(14041-87-3)
• EPA Substance Registry System: N,N'-DICYCLOHEXYLSULFAMIDE(14041-87-3)

Safety Data

• Hazardous Substances Data: 14041-87-3(Hazardous Substances Data)

Usage

General Description

N,N'-Dicyclohexylsulfamide is a chemical compound commonly used as a complexing agent and catalyst in organic reactions, particularly in the production of pharmaceuticals and agrochemicals. It is a cyclic sulfamide compound with two cyclohexyl groups attached to a sulfur atom, and it is known for its high thermal stability and solubility in organic solvents. N,N'-Dicyclohexylsulfamide is also used as a solvent in the separation and purification of certain metals, including uranium and plutonium, due to its ability to form stable complexes with these metals. Additionally, it has applications in the production of polymers, plasticizers, and dyes. The chemical is considered relatively low in toxicity and environmental impact, but proper handling and storage procedures should still be followed to minimize potential hazards.

Upstream product

• 108-91-8 cyclohexylamine 
• 139-05-9 sodium cyclamate 
• 14041-86-2 1,3-Dicyclohexyl-1,3-bis-<2-cyan-aethyl>-schwefelsaeure-diamid 

Downstream Products

• 69555-70-0 2,6-dicyclohexyl-(2,3,5,6-tetrahydro)-1,2,6-thiadiazin-3,5-dione 1,1-dioxide 
• 14041-86-2 1,3-Dicyclohexyl-1,3-bis-<2-cyan-aethyl>-schwefelsaeure-diamid 
• 23414-88-2 Schwefelsaeure-bis- 
• 102127-63-9 4-n-butyl-2,6-dicyclohexyl-1,2,6-thiadiazin-3,5-(2H,6H)-dione 1,1-dioxide 
• 32137-21-6 cyclohexylhydrazone of cyclohexanone 
• 2159-74-2 Azocyclohexan 
• 91556-35-3 1,3-Dicyclohexyl-1,3-dichlor-schwefelsaeure-diamid 

Relevant articles and documents

3D-QSAR design of novel antiepileptic sulfamides

A three-dimensional quantitative structure-activity relationship method, the comparative molecular field analysis (CoMFA), was applied to design new anticonvulsant symmetric sulfamides. The training set (27 structures) was comprised by traditional and new-generation anticonvulsant (AC) ligands that exhibit a potent activity in MES test. Physicochemical determinants of binding, such as steric and electrostatic properties, were mapped onto the molecular structures of the set, in order to interpret graphically the CoMFA results in terms of field contribution maps. The 3D-QSAR models demonstrate a good ability to predict the activity of the designed compounds (r2 = 0.967, q2 = 0.756).

Ultrasonic assisted green protocol for the synthesis of sulfamides

An improved environmentally benign method for synthesis of sulfamides under focused ultrasound irradiation and under solvent-free and catalyst-free conditions has been carried out by the reaction of amines or amino esters with sulfuryl chloride. This approach allows the synthesis of products in excellent yields and in short reaction time.

Microwave-assisted synthesis of some substituted sulfamides

Microwave-assisted synthesis of some substituted open-chain and cyclic sulfamides, by amine-exchange reaction, was studied in a modified domestic microwave oven. Reaction times and yields under microwave radiation were compared with classical heating. Synthesis of the sulfamides under microwave irradiation gave better yields with the desired compounds, and in considerably reduced reaction times, than those obtained by classical heating. [Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional figures.]