140413-44-1

Basic information

• Product Name: 2-CHLORO-4,6-DIMETHYLNICOTINAMIDE
• Synonyms: 2-CHLORO-4,6-DIMETHYLNICOTINAMIDE;IFLAB-BB F2113-0046;2-CHLORO-4,6-DIMETHYLPYRIDINE-3-CARBOXAMIDE;2-chloro-4,6-dimethyl-3-Pyridinecarboxamide
• CAS NO: 140413-44-1
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.62
• Mol File: 140413-44-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 154-155 °C(Solv: ethanol (64-17-5))
• Boiling Point: 270.7 °C at 760 mmHg
• Flash Point: 117.5 °C
• Appearance: /
• Density: 1.265 g/cm³
• Vapor Pressure: 0.00672mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: 2-8°C
• PKA: 14.42±0.50(Predicted)
• CAS DataBase Reference: 2-CHLORO-4,6-DIMETHYLNICOTINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4,6-DIMETHYLNICOTINAMIDE(140413-44-1)
• EPA Substance Registry System: 2-CHLORO-4,6-DIMETHYLNICOTINAMIDE(140413-44-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 140413-44-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Medicinal Chemistry, 35, p. 1887, 1992 DOI: 10.1021/jm00088a027

InChI:InChI=1/C8H9ClN2O/c1-4-3-5(2)11-7(9)6(4)8(10)12/h3H,1-2H3,(H2,10,12)

Upstream product

• 769-28-8 2-hydroxy-4,6-dimethyl-3-carbonitrile 
• 769-28-8 3-Cyano-4,6-dimethyl-2(1H)-pyridon 
• 14237-71-9 2-chloro-4,6-dimethylnicotinonitrile 

Downstream Products

• 72456-83-8 4,6-dimethyl-2-anilinonicotinamide 
• 140413-41-8 N-(2-chloro-4,6-dimethyl-3-pyridyl)salicylamide 
• 140413-10-1 2,4,5-trimethylpyrido<2,3-b><1,4>benzoxazepin-6(5H)-one 
• 66662-48-4 2-chloro-4,6-dimethylnicotinic acid 
• 82756-15-8 4,6-dimethyl-2-(p-bromoanilino)nicotinamide 
• 140413-40-7 3-amino-2-chloro-4,6-dimethylpyridine 
• 28491-67-0 4,6-dimethyl-3-oxo-2,3-dihydro-1H-pyrazolo<3,4-b>pyridine 

Relevant articles and documents

Synthesis of some halogen- and nitro-substituted nicotinic acids and their fragmentation under electron impact

Features of electrophilic and nucleophilic substitution under chlorination and nitration reactions conditions have been investigated for 6-hydroxy- and 6-methyl-substituted derivatives of 3-cyano-4-methyl-2(1H)-pyridones. The polychloro- and nitro-substituted 3-cyano-4-methylpyridines obtained were used as synthons in the synthesis of some polyhalo- and nitro-substituted nicotinic acids and their amides. The fragmentation pathways of the synthesized compounds under electron impact have been studied.

NUCLEOPHILIC SUBSTITUTION REACTIONS IN 2-CHLOROPYRIDINES AND 2,5-DIOXO-1,2,5,7-TETRAHYDRO-1H-FUROPYRIDINES

3-Cyano- and 3-carbamoyl-2-chloropyridines react with hydrazine hydrate to form substituted 3-amino-1H-pyrazolopyridines and 3-oxo-2,3-dihydro-1H-pyrazolopyridines.Hydrazine hydrate reacts with 3-carbamoyl-2-chloro-5-oxo-5,7-dihydrofuro3,4-