1404285-91-1Relevant academic research and scientific papers
Improvement of σ1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones
Meyer, Christina,Neue, Benedikt,Schepmann, Dirk,Yanagisawa, Shuichi,Yamaguchi, Junichiro,Würthwein, Ernst-Ulrich,Itami, Kenichiro,Wünsch, Bernhard
, p. 1844 - 1856 (2013/04/24)
The direct C-H-bond arylation of the complex spirocyclic lactones 13, 14, and 18 allows the introduction of diverse aryl moieties in the last step of the synthesis. A selective α-arylation of the thiophene moiety was performed with the catalytic system Pd
Late-stage C-H bond arylation of spirocyclic σ1 ligands for analysis of complementary σ1 receptor surface
Meyer, Christina,Schepmann, Dirk,Yanagisawa, Shuichi,Yamaguchi, Junichiro,Itami, Kenichiro,Wuensch, Bernhard
, p. 5972 - 5979 (2013/01/15)
Direct C-H bond arylation in the α- and β-positions of spirocyclic thiophenes containing various functional groups (amine, ether, acetal, lactone) was accomplished. Selective phenylation in the α-position of the thiophene ring was achieved by using the ca
