1404322-58-2Relevant academic research and scientific papers
Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond to Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain
Fuchino, Kouki,Mitsuoka, Yasunori,Masui, Moriyasu,Kurose, Noriyuki,Yoshida, Shuhei,Komano, Kazuo,Yamamoto, Takahiko,Ogawa, Masayoshi,Unemura, Chie,Hosono, Motoko,Ito, Hisanori,Sakaguchi, Gaku,Ando, Shigeru,Ohnishi, Shuichi,Kido, Yasuto,Fukushima, Tamio,Miyajima, Hirofumi,Hiroyama, Shuichi,Koyabu, Kiyotaka,Dhuyvetter, Deborah,Borghys, Herman,Gijsen, Harrie J.M.,Yamano, Yoshinori,Iso, Yasuyoshi,Kusakabe, Ken-Ichi
, p. 5122 - 5137 (2018/05/23)
Accumulation of Aβ peptides is a hallmark of Alzheimer's disease (AD) and is considered a causal factor in the pathogenesis of AD. β-Secretase (BACE1) is a key enzyme responsible for producing Aβ peptides, and thus agents that inhibit BACE1 should be bene
