1404367-16-3Relevant articles and documents
Synthesis of tetrahydroisoquinolines through TiCl4-mediated cyclization and Et3SiH reduction
Shi, Zeyu,Xiao, Qiong,Yin, Dali
supporting information, p. 729 - 732 (2019/10/02)
A versatile and efficient telescoped reaction sequence for the synthesis of tetrahydroisoquinolines (THIQs) is reported that uses TiCl4 to promote cyclization of a benzylaminoacetal derivative and Et3SiH for reduction of the intermediate 4-hydroxy-THIQ. This method is complimentary to the classical Pomeranz-Fritsch and related reactions since it tolerates electron-withdrawing substituents and allows access to 8-substituted THIQs.
ALDOSTERONE SYNTHASE INHIBITORS
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Page/Page column 59, (2012/11/13)
This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.