1404368-39-3Relevant academic research and scientific papers
Synthesis, characterization and antimicrobial studies of new bispyrazolines linked via 3-aryl ring with aliphatic chains
Yusuf, Mohamad,Jain, Payal
, p. 295 - 304 (2012)
The bispyrazolines 4a(a′-f′) and 4b(a′-f′) built around the aliphatic chains of varying lengths have been prepared by refluxing bischalcones 3a(a′-f′) and 3b(a′-f′) with phenyl hydrazine in alcoholic medium. The reactions of chalcones 2a and 2b with suitable 1,ω-dibromoalkanes in the presence of anhydrous K 2CO3/dry acetone and Bu4N+I - (PTC) provided 3a(a′-f′) and 3b(a′-f′), respectively. The antibacterial and antifungal activities of the synthesized compounds were evaluated against five bacterial and four fungal strains. The compounds 3ba′, 3bc′, 3bd′, 3be′, 3af′, 4aa′ and 4ba′ showed better MIC (μg/mL) against the tested microorganisms.
