1404375-73-0

Basic information

• Product Name: 5-[1-(3-carboxy-benzyl)-piperidin-3-ylamino]-indazole-1-carboxylic acid tert-butyl ester
• Synonyms: 5-[1-(3-carboxy-benzyl)-piperidin-3-ylamino]-indazole-1-carboxylic acid tert-butyl ester
• CAS NO: 1404375-73-0
• Molecular Weight: 450.538
• Mol File: 1404375-73-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-[1-(3-carboxy-benzyl)-piperidin-3-ylamino]-indazole-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[1-(3-carboxy-benzyl)-piperidin-3-ylamino]-indazole-1-carboxylic acid tert-butyl ester(1404375-73-0)
• EPA Substance Registry System: 5-[1-(3-carboxy-benzyl)-piperidin-3-ylamino]-indazole-1-carboxylic acid tert-butyl ester(1404375-73-0)

Safety Data

• Hazardous Substances Data: 1404375-73-0(Hazardous Substances Data)

Upstream product

• 916991-31-6 5-(1-benzyl-piperidin-3-ylamino)-indazole-1-carboxylic acid tert-butyl ester 
• 129488-10-4 5-Amino-indazole-1-carboxylic acid tert-butyl ester 
• 129488-09-1 5-nitro-indazole-1-carboxylic acid tert-butyl ester 
• 5401-94-5 5-nitroindazole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 916989-48-5 5-(piperidin-3-ylamino)-indazole-1-carboxylic acid tert-butyl ester 
• 619-21-6 m-formylphenyl benzoic acid 

Downstream Products

• 1404375-54-7 C₂₈H₂₉N₅O₃ 
• 1404375-45-6 C₂₆H₃₁N₅O₃S 

Relevant articles and documents

NOVEL ROCK INHIBITORS

The present invention relates to new kinase inhibitors of Formula (I), wherein X is oxygen, —NH—, or a direct bond; Y is —NH— or a direct bond; n is an integer from 0 to 4; m is an integer from 0 to 4; Cy represents a bivalent radical consisting of a satured (poly)cycle, including fused, bi-, spiro or bridged carbocycles and heterocycles; in particular selected from the group consisting of: Formula (II), Ar is selected from the group comprising: Formula (III), R2 is hydrogen or methyl; R8 is hydrogen, methyl, halogen, or alkynyl; R1 is an aryl or heteroaryl more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.