140440-46-6 Usage
Chemical compound
2-amino-9-[(1S,4R,5R)-4,5-bis(hydroxymethyl)cyclopent-2-en-1-yl]-3,9-dihydro-6H-purin-6-one
Also known as
N9-(1-phosphono-β-D-ribosyl)adenine-3-(2-hydroxyethyl) phosphate
Modified purine nucleotide
Potential antiviral activity
Studied for potential use as an antiviral drug
Activity against herpes simplex virus, human cytomegalovirus, varicella-zoster virus, and Epstein-Barr virus
Functions by inhibiting viral DNA polymerase and viral DNA replication
Potential as a treatment for viral infections in medical research.
Check Digit Verification of cas no
The CAS Registry Mumber 140440-46-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,4,4 and 0 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 140440-46:
(8*1)+(7*4)+(6*0)+(5*4)+(4*4)+(3*0)+(2*4)+(1*6)=86
86 % 10 = 6
So 140440-46-6 is a valid CAS Registry Number.
140440-46-6Relevant articles and documents
Synthesis and anti-HIV activity of 9-[e-4,t-5-bis(hydroxymethyl)cyclopent- 2-en-r-1-yl]-9H-adenine
Katagiri,Nomura,Sato,Kaneko,Yusa,Tsuruo
, p. 1882 - 1886 (2007/10/02)
The synthesis and in vitro anti-HIV activity of two new racemic nucleoside analogues are described; namely, 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en- r-1-yl]-9H-adenine (12) and its guanine analogue 18. While the latter (18) showed no activity, the therapeutic index of the former (12) was 200 and comparable to that (400) of carbovir. One enantiomer of 12 may be viewed as an analogue of carbocyclic oxetanocin and the other as an analogue of carbovir. Hence, these results indicate that one or both of the individual enantiomers of 12 could serve as candidates or lead compounds for the development of anti-AIDS agents.