1404476-88-5Relevant academic research and scientific papers
Synthesis of N2-arylaminopyrimidine-5-carbonitrile derivatives via SNAr amination reaction
Rostamizadeh, Shahnaz,Nojavan, Masoomeh,Aryan, Reza
, p. 152 - 156 (2015)
An efficient and high-yielding synthesis of N2-arylaminopyrimidine-5-carbonitrile derivatives starting from arylamines and 2-methylthio-pyrimidine-5-carbonitrile derivatives has been developed in the presence of cesium carbonate as basic reagent. This new protocol showed high chemical tolerance for a range of functional groups, and only the methylthio substituent on C2 of the pyrimidine ring was replaced with arylamine derivatives under the reaction conditions.
An environmentally benign multicomponent synthesis of some novel 2-methylthio pyrimidine derivatives using MCM-41-NH2 as nanoreactor and nanocatalyst
Rostamizadeh, Shahnaz,Nojavan, Masoomeh
, p. 418 - 422 (2014/04/17)
Some novel 4-amino-6-aryl-2-methylthio pyrimidine-5-carbonitrile derivatives were synthesized through a one-pot three-component reaction of an aldehyde, malononitrile, and S-methylisothiouronium iodide, using MCM-41-NH 2 as nanoreactor and nanocatalyst. This protocol has some advantages including application of readily available and nonhazardous materials, benign reaction conditions (ambient temperature, solvent-free, and one-pot approach), easy work-up, and high overall yields of the products.
